Phase plane analysis in R
As an example I use here the FitzHugh-Nagumo system introduced earlier:
\begin{align}
\dot{v}=&2 (w + v - \frac{1}{3}v^3) + I_0 \\
\dot{w}=&\frac{1}{2}(1 - v - w)\\
\end{align}
The FitzHugh-Nagumo system is a simplification of the Hodgkin-Huxley model of spike generation in squid giant axon. Here \(I_0\) is a bifurcation parameter. As I decrease \(I_0\) from 0 the system dynamics change (Hopf-bifurcation): a stable equilibrium solution transform into a limit cycle.
Following Michael's paper, I can use
phaseR to plot the velocity field, add nullclines and plot trajectories from different starting points.Here I plot the FitzHugh-Nagumo system for four different parameters of \(I_0\) and three different initial starting values. The blue line show the nullcline of \(w\) i.e. \(\dot{w}=0\), while the red line shows the nullcline of \(v\). For \(I_0=-2\) I can observe the limit cycle.
Yet, I was a little surprised that the paper didn't make any references to the XPPAUT software by Bard Ermentrout, which has been around for many years as tool to analyse dynamical systems.
The GUI to the software itself gives many more options to analyse dynamical systems, including an interface to the popular bifurcation program AUTO. A good tutorial with the FitzHugh-Nagumo model was given by Mathieu Desroches at the ICS summer school 2012.
Of course I could use XPPAUT as a pure integration engine from R as well:
Considering that R started as a tool for statisticians it has made a remarkable journey; here competing with more traditional engineering tools like Matlab with MatCont or special software like XPPAUT. If someday, someone would find the time and motivation to write an interface to AUTO then R would indeed be a very good environment for the analysis of dynamical systems.
Session Info
R version 3.1.2 (2014-10-31)
Platform: x86_64-apple-darwin13.4.0 (64-bit)
locale:
[1] en_GB.UTF-8/en_GB.UTF-8/en_GB.UTF-8/C/en_GB.UTF-8/en_GB.UTF-8
attached base packages:
[1] stats graphics grDevices utils datasets methods
[7] base
other attached packages:
[1] phaseR_1.3 deSolve_1.10-9
loaded via a namespace (and not attached):
[1] tools_3.1.2Hodgkin-Huxley model in R
One of the great research papers of the 20th century celebrates its 60th anniversary in a few weeks time: A quantitative description of membrane current and its application to conduction and excitation in nerve by Alan Hodgkin and Andrew Huxley. Only shortly after Andrew Huxley died, 30th May 2012, aged 94.
In 1952 Hodgkin and Huxley published a series of papers, describing the basic processes underlying the nervous mechanisms of control and the communication between nerve cells, for which they received the Nobel prize in physiology and medicine, together with John Eccles in 1963.
Their research was based on electrophysiological experiments carried out in the late 1940s and early 1950 on a giant squid axon to understand how action potentials in neurons are initiated and propagated.
